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Communication Dans Un Congrès Année : 2010

Non-negative Matrix Factorization: a blind sources separation method applied to optical fluorescence spectroscopy and multiplexing

Résumé

Fluorescence optical imaging use one or several (in multiplexing) injected fluorescent markers which specifically bind to targeted compounds. Near infrared light illuminates the region of interest and the emitted fluorescence is analyzed to localize fluorescence sources. A spectroscopic approach and a separation source method (Nonnegative matrix factorization) are explored to separate di fferent fluorescence sources and remove the unwanted biological tissues autofluorescence. We present unmixing results on overlapping spectra of interest, and show that autofluorescence removal improves Fluorescent Diffuse Optical Tomography
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hal-00583109 , version 1 (04-04-2011)

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  • HAL Id : hal-00583109 , version 1

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Anne-Sophie Montcuquet, Lionel Herve, Jean-Marc Dinten, Jerome I. Mars. Non-negative Matrix Factorization: a blind sources separation method applied to optical fluorescence spectroscopy and multiplexing. Biomedical Optics BIOS congress, Jan 2010, San Francisco, United States. Proceeding SPIE-OSA Biomedical Applications of Light Scattering IV, Vol. 7573, 757314. ⟨hal-00583109⟩
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