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Article Dans Une Revue Synthesis: Journal of Synthetic Organic Chemistry Année : 2011

Highly Convenient Gram-Scale Solution-Phase Peptoid Synthesis and Orthogonal Side-Chain Post-Modification

Résumé

This paper describes the development of a highly convenient solution-phase methodology using volatile amines for the synthesis of β-, α,β- and α-tetrapeptoids, as an alternative to solid-phase technologies. Column chromatographic purifications are reduced to a minimum and the majority of the intermediates are purified by filtration and/or evaporation. The method is amenable to gram-scale synthesis of peptoids, and post-modification of a model peptoid by successive and selective ligations, using click thiol-ene coupling, and copper-catalysed azide-alkyne cycloaddition is demonstrated
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Dates et versions

hal-00561036 , version 1 (31-01-2011)

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  • HAL Id : hal-00561036 , version 1

Citer

Cécile Caumes, Thomas Hjelmgaard, Roland Remuson, Sophie Faure, Claude Taillefumier. Highly Convenient Gram-Scale Solution-Phase Peptoid Synthesis and Orthogonal Side-Chain Post-Modification. Synthesis: Journal of Synthetic Organic Chemistry, 2011, pp.257-264. ⟨hal-00561036⟩
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