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Article Dans Une Revue Tetrahedron Letters Année : 2010

Synthesis and ligation ability of mono-aminooxy-functionalized dendrigraft poly-l-lysine (DGL)

Résumé

A bifunctional tetraethylene glycol (TEG) linker was prepared and used as an initiator for the synthesis of the first two generations of dendrigraft poly-l-lysines (DGL). The key steps involved the desymmetrization of TEG by introduction of an amine group after activation of a terminal hydroxyl group and of a conveniently protected aminooxy functionality at the other end. Initiation of l-lysine N-carboxyanhydride polymerization by the terminal amine yielded generations 1 and 2 of DGL in which a subsequent functionalization of the aminooxy group by ligation with entities bearing an aldehyde group turned out to be feasible.

Dates et versions

hal-00554410 , version 1 (10-01-2011)

Identifiants

Citer

Andrea Molero Bondia, Nicolas Larcher, Laurent Garrelly, Jean-Christophe Rossi, Robert Pascal. Synthesis and ligation ability of mono-aminooxy-functionalized dendrigraft poly-l-lysine (DGL). Tetrahedron Letters, 2010, 51 (25), pp.3330-3333. ⟨10.1016/j.tetlet.2010.04.078⟩. ⟨hal-00554410⟩
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