Effects of a 5-HT3 antagonist, ondansetron, on fasting and postprandial small bowel water content assessed by magnetic resonance imaging - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Alimentary Pharmacology and Therapeutics Année : 2010

Effects of a 5-HT3 antagonist, ondansetron, on fasting and postprandial small bowel water content assessed by magnetic resonance imaging

Résumé

Background 5-HT3 antagonists have been shown to be effective in relieving symptoms of IBS-D. Using a recently validated MRI method we have demonstrated reduced fasting small bowel water content (SBWC) in IBS-D associated with accelerated small bowel transit. We hypothesized that slowing of transit with ondansetron would lead to an increase in SBWC by inhibiting fasting motility. Aim To assess the effects of ondansetron compared with placebo in healthy volunteers on SBWC and motility, one group studied using MRI and one using manometry. Methods Healthy volunteers were given placebo or ondansetron on the day prior to and on the study day. n=16 underwent baseline fasting and postprandial MRI scans. In a second study, a separate n=18 group was intubated and overnight MMC recorded. Baseline MRI scans were carried out after tube removal. Results Fasting SBWC was markedly increased by ondansetron (P <0.0007). Ondansetron reduced the overall antroduodenal Motility Index (P <0.04). The subjects who were intubated had significantly lower fasting SBWC (P <0.0002) compared to the group of subjects who were not intubated. Conclusions 5-HT3 receptor antagonism increased fasting small bowel water. This was associated with reduced fasting antroduodenal Motility Index which may explain the clinical benefit of such drugs.

Mots clés

Fichier principal
Vignette du fichier
PEER_stage2_10.1111%2Fj.1365-2036.2010.04395.x.pdf (668.78 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-00553740 , version 1 (09-01-2011)

Identifiants

Citer

Luca Marciani, Jeff Wright, Stephen Foley, Caroline L Hoad, John J Totman, et al.. Effects of a 5-HT3 antagonist, ondansetron, on fasting and postprandial small bowel water content assessed by magnetic resonance imaging. Alimentary Pharmacology and Therapeutics, 2010, ⟨10.1111/j.1365-2036.2010.04395.x⟩. ⟨hal-00553740⟩

Collections

PEER
90 Consultations
369 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More