Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Immunity Année : 2010

Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes.

Résumé

Regulatory T (Treg) cells limit the onset of effective antitumor immunity, through yet-ill-defined mechanisms. We showed the rejection of established ovalbumin (OVA)-expressing MCA101 tumors required both the adoptive transfer of OVA-specific CD8(+) T cell receptor transgenic T cells (OTI) and the neutralization of Foxp3(+) T cells. In tumor-draining lymph nodes, Foxp3(+) T cell neutralization induced a marked arrest in the migration of OTI T cells, increased numbers of dendritic cells (DCs), and enhanced OTI T cell priming. Using an in vitro cytotoxic assay and two-photon live microscopy after adoptive transfer of DCs, we demonstrated that Foxp3(+) T cells induced the death of DCs in tumor-draining lymph nodes, but not in the absence of tumor. DC death correlated with Foxp3(+) T cell-DC contacts, and it was tumor-antigen and perforin dependent. We conclude that Foxp3(+) T cell-dependent DC death in tumor-draining lymph nodes limits the onset of CD8(+) T cell responses.

Domaines

Immunologie

Dates et versions

hal-00553080 , version 1 (06-01-2011)

Identifiants

Citer

Alexandre Boissonnas, Alix Scholer-Dahirel, Virginie Simon-Blancal, Luigia Pace, Fabien Valet, et al.. Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes.. Immunity, 2010, 32 (2), pp.266-78. ⟨10.1016/j.immuni.2009.11.015⟩. ⟨hal-00553080⟩
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