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Article Dans Une Revue Cytokine & Growth Factor Reviews Année : 2010

The resolution of inflammation and cancer.

Résumé

Inflammation has long been thought to contribute to the development of cancer; however there is also clear evidence that the immune system can recognize and eliminate cancer cells. Current research suggests that cancer-associated inflammation has a dual role in tumor progression; inflammatory mediators promote the malignant activity of cancer cells by acting as growth factors and also stimulate angiogenesis, however, cancer-associated inflammation is also linked with immune-suppression that allows cancer cells to evade detection by the immune system. In this review we will discuss the dual role of inflammation in cancer and how endogenous anti-inflammatory mechanisms may equally be important in carcinogenesis.

Domaines

Immunologie

Dates et versions

hal-00553068 , version 1 (06-01-2011)

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Citer

Juan Rodriguez-Vita, Toby Lawrence. The resolution of inflammation and cancer.. Cytokine & Growth Factor Reviews, 2010, 21 (1), pp.61-5. ⟨10.1016/j.cytogfr.2009.11.006⟩. ⟨hal-00553068⟩
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