BORTEZOMIB EFFECTIVENESS IN ONE PATIENT WITH ACQUIRED VON WILLEBRAND SYNDROME ASSOCIATED TO MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue American Journal of Hematology Année : 2010

BORTEZOMIB EFFECTIVENESS IN ONE PATIENT WITH ACQUIRED VON WILLEBRAND SYNDROME ASSOCIATED TO MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE

Mario Ojeda Uribe
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Claudine Caron
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Agathe Debliquis
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Résumé

Acquired von Willebrand Syndrome (AVWS) is a rare heterogeneous bleeding condition associated with several disorders, including monoclonal gammopathy of undeterminated significance (MGUS) [1-3]. Successful therapy of the underlying disorder can leads to the improvement of AVWS [1]. Regarding the association of AVWS and MGUS, no long-term successful therapy has been reported. Indeed, most of these patients are not treated on a curative goal [1]. In a few single cases anti-CD20 targeted therapy (Rituximab) has shown no efficacy [4,5]. We describe herein the case of a patient with AVWS accompanied by MGUS who was successfully treated with the proteosome inhibitor Bortezomib after failure of Rituximab.

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Dates et versions

hal-00552313 , version 1 (06-01-2011)

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Mario Ojeda Uribe, Claudine Caron, Nathalie Itzhar-Baikian, Agathe Debliquis. BORTEZOMIB EFFECTIVENESS IN ONE PATIENT WITH ACQUIRED VON WILLEBRAND SYNDROME ASSOCIATED TO MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE. American Journal of Hematology, 2010, ⟨10.1002/ajh.21692⟩. ⟨hal-00552313⟩

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