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Article Dans Une Revue Journal of Organic Chemistry Année : 2010

Synthesis of the landomycinone skeleton.

Résumé

The synthesis of the highly functionalized tetracyclic skeleton of landomycinone (2), the aglycon of landomycins, was performed using two pivotal steps relying on metal-catalyzed reactions. They are (1) a [2 + 2 + 2] cycloaddition of alkynes promoted by Wilkinson's catalyst to build rings B and C concomitantly and (2) a ring-closing metathesis followed by aromatization to build ring D.

Domaines

Chimie organique
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Dates et versions

hal-00551621 , version 1 (04-01-2011)

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Xavier Bugaut, Xavier Guinchard, Emmanuel Roulland. Synthesis of the landomycinone skeleton.. Journal of Organic Chemistry, 2010, 75 (23), pp.8190-8. ⟨10.1021/jo1018377⟩. ⟨hal-00551621⟩
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