A new quisqualate receptor subtype (sAA(2)) responsible for the glutamate-induced inositol phosphate formation in rat brain synaptoneurosomes. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Neurochemistry International Année : 1988

A new quisqualate receptor subtype (sAA(2)) responsible for the glutamate-induced inositol phosphate formation in rat brain synaptoneurosomes.

Résumé

Inositol phosphate synthesis elicited by excitatory amino acids was measured in rat forebrain synaptoneurosomes in presence of Li(+). Quisqualate (QA) was the most potent excitatory amino acid inducing inositol phosphate formation. This QA action was not blocked by any of the usual antagonists [glutamate-amino-methyl-sulphonate (GAMS); glutamate-diethyl-ester (GDEE); ?-d-glutamyl-glycine (?-DGG)] known to inhibit the QA-induced depolarization. The same was found for the most potent and selective QA antagonist reported so far [6-nitro-7-cyanoquinoxaline-2,3-dion (FG 9065)]. In addition, dl-?-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) a potent depolarizing agonist at the quisqualate receptor subtype was about 300 times less potent than quisqualate in increasing inositol phosphate accumulation. Our results provide the first pharmacological evidence indicating that a new quisqualate receptor subtype, tentatively termed sAA(2) is responsible for inositol phosphate formation.

Domaines

Neurobiologie

Dates et versions

hal-00542145 , version 1 (20-08-2019)

Identifiants

Citer

Max Récasens, Janique Guiramand, Agnès Nourigat, Isabelle Sassetti, Ginette Devilliers. A new quisqualate receptor subtype (sAA(2)) responsible for the glutamate-induced inositol phosphate formation in rat brain synaptoneurosomes.. Neurochemistry International, 1988, 13 (4), pp.463-467. ⟨10.1016/0197-0186(88)90075-7⟩. ⟨hal-00542145⟩
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