Gd(DO3A-N-alpha-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2009

Gd(DO3A-N-alpha-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents

Miguel Ferreira
  • Fonction : Auteur
Andre Martins
  • Fonction : Auteur
A. Martins Jose
  • Fonction : Auteur
Paula Ferreira
  • Fonction : Auteur
F.G.C. Geraldes Carlos
  • Fonction : Auteur

Résumé

We report the synthesis of a novel, versatile and easily accessible metal chelator, DO3A-N-alpha-aminopropionate, and the relaxometric characterization of its Gd3+ complex, revealing great potential for the development of high relaxivity targeted contrast agents for magnetic resonance imaging.

Dates et versions

hal-00522392 , version 1 (30-09-2010)

Identifiants

Citer

Miguel Ferreira, Andre Martins, A. Martins Jose, Paula Ferreira, Éva Tóth, et al.. Gd(DO3A-N-alpha-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents. Chemical Communications, 2009, 42, pp.6475-6477. ⟨10.1039/b912201j⟩. ⟨hal-00522392⟩
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