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Article Dans Une Revue International Urogynecology Journal Année : 2010

Correlation between shrinkage and infection of implanted synthetic meshes using an animal model of mesh infection.

Résumé

INTRODUCTION AND HYPOTHESIS: The aim of this study was to evaluate a link between mesh infection and shrinkage. METHODS: Twenty-eight Wistar rats were implanted with synthetic meshes that were either non-absorbable (polypropylene (PP), n = 14) or absorbable (poly (D: ,L: -lactic acid) (PLA94), n = 14). A validated animal incisionnal abdominal hernia model of mesh infection was used. Fourteen meshes (n = 7 PLA94 and n = 7 PP meshes) were infected intraoperatively with 10e6 CFU Escherichia coli, and compared with 14 non-infected meshes (n = 7 PLA94 and n = 7 PP meshes) (control groups). Explantations were performed on day 30. Shrinkage was evaluated by a reproducible numerical analysis of mesh area. Infection and histological study were evaluated on day 30. RESULTS: Non-infected meshes were less shrunk than infected meshes for both non-absorbable (5.0 +/- 1.7% versus 21.6 +/- 6.1%, p < 0.05) and absorbable meshes (2.4 +/- 0.9% versus 11.0 +/- 2.5%, p < 0.05). CONCLUSION: This study highlights a link between infection and shrinkage in the model used.

Domaines

Biomatériaux
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Dates et versions

hal-00519948 , version 1 (21-09-2010)

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Laurent Mamy, Vincent Letouzey, Jean-Philippe Lavigne, Xavier Garric, Jean Gondry, et al.. Correlation between shrinkage and infection of implanted synthetic meshes using an animal model of mesh infection.. International Urogynecology Journal, 2010, epub ahead of print. ⟨10.1007/s00192-010-1245-7⟩. ⟨hal-00519948⟩
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