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Article Dans Une Revue Journal of Molecular Catalysis B: Enzymatic Année : 2010

Lipase-catalyzed synthesis and characterization of novel lipidyl-cyclodextrins in solvent free medium

Véronique Bonnet
Carine Avondo
Fredéric Aubry
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  • PersonId : 1358415
Florence Djedaïni-Pilard
Catherine Sarazin

Résumé

The lipase-catalyzed amidation reaction between fatty acyl donors and mono-6-amino-permethylated β-cyclodextrin (MBCD-NH2) was achieved with high yield in solvent free medium. The ability of Mucor miehie and Candida cylindracea lipases, free or immobilized, to catalyze amidation reaction was shown. Products were purified and characterized. To optimize the reaction, some reaction conditions were assessed like temperature, type of shaking and amount of enzyme, on a model amidation reaction between butyl caprylate and MBCD-NH2. Among the biocatalysts tested, Lipozyme was found to be the most active, requiring low loading, being robust at 70 °C even under magnetic agitation.

Domaines

Chimie

Dates et versions

hal-00516825 , version 1 (11-09-2010)

Identifiants

Citer

Audrey Favrelle, Véronique Bonnet, Carine Avondo, Fredéric Aubry, Florence Djedaïni-Pilard, et al.. Lipase-catalyzed synthesis and characterization of novel lipidyl-cyclodextrins in solvent free medium. Journal of Molecular Catalysis B: Enzymatic, 2010, 66 (1-2), pp.224-227. ⟨10.1016/j.molcatb.2010.05.013⟩. ⟨hal-00516825⟩
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