Designing hyaluronic acid-based layer-by-layer capsules as a carrier for intracellular drug delivery - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biomacromolecules Année : 2010

Designing hyaluronic acid-based layer-by-layer capsules as a carrier for intracellular drug delivery

Résumé

Polyelectrolyte microcapsules were prepared by the layer-by-layer assembly of hyaluronic acid (HA) and a polycationic polymer, poly(allylamine) (PAH) or poly(lysine) (PLL). The influence of the polycationic partner on the morphology, stability, permeability properties, and enzymatic degradation of microcapsules was thoroughly analyzed. It was found that these properties could be tuned by shell cross-linking. Confocal microscopy studies of cellular uptake of the capsules showed that the polyelectrolyte shells remain stable outside the cells but readily break open once internalized by cells, suggesting their potential as carrier for intracellular drug delivery.
Fichier non déposé

Dates et versions

hal-00499338 , version 1 (09-07-2010)

Identifiants

Citer

Anna Szarpak, Di Cui, Frédéric Dubreuil, Bruno de Geest, Liesbeth de Cock, et al.. Designing hyaluronic acid-based layer-by-layer capsules as a carrier for intracellular drug delivery. Biomacromolecules, 2010, 11 (3), pp.713-720. ⟨10.1021/bm9012937⟩. ⟨hal-00499338⟩
68 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More