Identification of a lysine-rich region of Fas as a raft nanodomain targeting signal necessary for Fas-mediated cell death. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Experimental Cell Research Année : 2010

Identification of a lysine-rich region of Fas as a raft nanodomain targeting signal necessary for Fas-mediated cell death.

Résumé

Fas interaction at the plasma membrane with its lipid and protein environment plays a crucial role in the early steps of Fas signalling induced by Fas ligand binding. Particularly, Fas localisation in the raft nanodomains, ezrin-mediated interaction with the actin cytoskeleton and subsequent internalization are critical steps in Fas-mediated cell death. We identified a lysine-rich region (LRR) in the cytoplasmic, membrane-proximal region of Fas as a key determinant modulating these initial events. Through a genetic approach, we demonstrate that Fas LRR represents another signal additional to palmitoylation targeting Fas to the raft nanodomains, and modulates Fas interaction with the cytoskeleton.

Dates et versions

hal-00497187 , version 1 (02-07-2010)

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Aurélie Rossin, Rosana Kral, Nadia Lounnas, Krittalak Chakrabandhu, Sébastien Mailfert, et al.. Identification of a lysine-rich region of Fas as a raft nanodomain targeting signal necessary for Fas-mediated cell death.. Experimental Cell Research, 2010, 316 (9), pp.1513-22. ⟨10.1016/j.yexcr.2010.03.002⟩. ⟨hal-00497187⟩
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