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Article Dans Une Revue Breast Cancer Research and Treatment Année : 2009

E-cadherin mediates the aggregation of breast cancer cells induced by tamoxifen and epidermal growth factor

Résumé

In the present study, we evaluated the ability of 4-hydroxytamoxifen (OHT) and epidermal growth factor (EGF) to regulate homotypic adhesion in MCF7 breast cancer cells. Our results demonstrate that OHT and EGF activate the E-cadherin promoter, increase E-cadherin mRNA and protein expression and enhance homotypic aggregation of MCF7 cells. Interestingly, an ERα and EGFR cross-talk is involved in the E-cadherin expression by OHT and EGF, as demonstrated by knocking down either receptor. On the basis of our findings, the well-established cross-talk between ERα and EGFR could be extended to the modulation of E-cadherin expression by OHT and EGF. Thus, the potential ability of tamoxifen to induce cell–cell aggregation may contribute to the biologic response of pharmacologic intervention in patients with breast cancer.
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Dates et versions

hal-00485062 , version 1 (20-05-2010)

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Loredana Mauro, Michele Pellegrino, Rosamaria Lappano, Adele Vivacqua, Francesca Giordano, et al.. E-cadherin mediates the aggregation of breast cancer cells induced by tamoxifen and epidermal growth factor. Breast Cancer Research and Treatment, 2009, 121 (1), pp.79-89. ⟨10.1007/s10549-009-0456-4⟩. ⟨hal-00485062⟩

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