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Article Dans Une Revue Transfusion Clinique et Biologique Année : 2010

[Extracorporeal photochemotherapy]

Résumé

Photopheresis or extracorporeal photochemotherapy (ECP) is a cellular therapy which combines a leukapheresis followed by ex vivo treatment using psoralen and ultraviolet A irradiation before reinfusion into the patient. Its mechanisms of action remain unclear and selective photodestruction of leukocytes cannot explain the long-lasting immunomodulatory effects. Recent studies demonstrated that ECP down regulates the immune response and induces tolerance through the maturation of dendritic cells and the production of regulatory T cells. Based on these effects, ECP is mainly used for treatment of Sezary syndrome, graft-versus-host disease, organ graft rejection and autoimmune diseases. However, it is still not clear how ECP both activates tumor immunity against cutaneous T-cell lymphoma and induces tolerance in autoreactive disorders. In addition, the use of adjuvant therapies, the long-term effects and various treatment protocols remain to be investigated along with the specific indications.

Domaines

Cancer

Dates et versions

hal-00484240 , version 1 (18-05-2010)

Identifiants

Citer

M. Viguier, F. Pouthier, Pierre Tiberghien, François Aubin. [Extracorporeal photochemotherapy]. Transfusion Clinique et Biologique, 2010, 17 (1), pp.28-33. ⟨10.1016/j.tracli.2009.10.005⟩. ⟨hal-00484240⟩
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