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Article Dans Une Revue Autophagy Année : 2006

SCRG1, a potential marker of autophagy in transmissible spongiform encephalopathies.

Résumé

The Scrg1 gene was initially discovered as one of the genes upregulated in transmissible spongiform encephalopathies (TSE). Scrg1 encodes a highly conserved, cysteine-rich protein expressed principally in the central nervous system. The protein is targeted to the Golgi apparatus and large dense-core vesicles/secretory granules in neurons. We have recently shown that the Scrg1 protein is widely induced in neurons of scrapie-infected mice, suggesting that Scrg1 is involved in the host response to stress and/or the death of neurons. At the ultrastructural level, Scrg1 is associated with dictyosomes of the Golgi apparatus and autophagic vacuoles of degenerative neurons. It is well known that apoptosis plays a major role in the events leading to neuronal cell death in TSE. However, autophagy was identified in experimentally induced scrapie a long time ago and was recently reevaluated as a possible cell death program in prion diseases. The consistent association of Scrg1 with autophagic structures typical of scrapie is in agreement with the recruitment of Golgi-specific proteins in this degradation process and we suggest that Scrg1 might be used as a specific probe to identify neuronal autophagy in TSE.
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Dates et versions

hal-00482212 , version 1 (10-05-2010)

Identifiants

  • HAL Id : hal-00482212 , version 1
  • PUBMED : 16874033

Citer

Michel Dron, Yannick Bailly, Vincent Béringue, Anne-Marie Haeberlé, Bernadette Griffond, et al.. SCRG1, a potential marker of autophagy in transmissible spongiform encephalopathies.. Autophagy, 2006, 2 (1), pp.58-60. ⟨hal-00482212⟩
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