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Article Dans Une Revue Pflügers Archiv European Journal of Physiology Année : 2009

Ciliar functions in the nephron.

Résumé

The primary cilium is a microtubule-based nonmotile organelle that is found on most cells in the mammalian body. Once regarded as a vestigial organelle, it has been recently shown to play unforeseen roles in mammalian physiology and tissue homeostasis. In kidney epithelial cells, the primary cilium plays a fundamental role in tubule organization and function and it is now considered to serve as a versatile mechanosensor and chemosensor. Diseases related to kidney primary cilia include autosomal polycystic kidney disease, recessive polycystic kidney disease, Bardet-Biedl syndrome, and nephronophthisis. Multiple proteins whose functions are disrupted in cystic kidney diseases have been localized in the primary cilium. This review provides a general introduction to the cell biology and function of renal primary cilia and an overview of cilia-related kidney diseases.

Dates et versions

hal-00481480 , version 1 (06-05-2010)

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Lise Rodat-Despoix, Patrick Delmas. Ciliar functions in the nephron.. Pflügers Archiv European Journal of Physiology, 2009, 458 (1), pp.179-87. ⟨10.1007/s00424-008-0632-0⟩. ⟨hal-00481480⟩

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