Dysphagia and hypervitaminosis A: cervical hyperostosis. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Joint Bone Spine Année : 2009

Dysphagia and hypervitaminosis A: cervical hyperostosis.

Chafika Hafsaoui
  • Fonction : Auteur
Jean-Marie Laurain
  • Fonction : Auteur
Michel Runge
  • Fonction : Auteur
Nadine Magy-Bertrand
  • Fonction : Auteur
Clément Prati
  • Fonction : Auteur
  • PersonId : 762349
  • IdRef : 144759942

Résumé

Vertebral hyperostosis typically predominates at the thoracic spine and causes only minor symptoms. Involvement of the cervical spine may cause dysphagia due to pressure on the esophagus. We report three cases of dysphagia revealing cervical hyperostosis. CASE REPORTS: The patients were 3 men aged 54-73 years. Dysphagia was moderate in 2 patients and severe in 1 patient who had lost 4 kg over 6 months. Stiffness of the neck with mild pain was present. One patient reported a neck injury in childhood and another had a brother and father with similar symptoms. Radiographs showed exuberant anterior cervical hyperostosis. Two patients also had hyperostotic changes at the thoracic spine and pelvis. The skin and neurological evaluation were normal. Findings were normal from standard blood tests (C-reactive protein, calcium, and vitamin D). Tests were negative for the HLA-B27 antigen in all 3 patients. Serum vitamin A levels were high, ranging from 894 to 1123 microg/L (normal, 489-720). None of the patients reported taking retinoids or having unusual eating habits. DISCUSSION: Dysphagia can result from anterior cervical hyperostosis. A role for hypervitaminosis A in the genesis of hyperostosis has long been suspected. In our patients, the absence of vitamin A supplementation suggests an abnormality in vitamin A metabolism.

Dates et versions

hal-00465263 , version 1 (19-03-2010)

Identifiants

Citer

Daniel Wendling, Chafika Hafsaoui, Jean-Marie Laurain, Michel Runge, Nadine Magy-Bertrand, et al.. Dysphagia and hypervitaminosis A: cervical hyperostosis.. Joint Bone Spine, 2009, 76 (4), pp.409-11. ⟨10.1016/j.jbspin.2008.11.004⟩. ⟨hal-00465263⟩

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