Dependent people have a great variability in their needs and levels of motor and/or cognitive handicap. Hence they call for personalized services, especially when interacting with their environment. In smart homes, the Semantic Matching Framework (SMF) provides an appropriate middleware for delivering personalized assistive services in line with the disabilities of a user. SMF is a system based on the Web Ontology Language (OWL) as a modeling language to define ontologies for modeling and reasoning on the user environment and its profile. This paper first, details the adopted approach to personalize a smart home to people with special needs. Then shows how SMF support and manage multiple-users