This paper reports a full-scale experimental campaign and a computational fluid dynamics (CFD) study of a radiant cooling ceiling installed in a test room, under controlled conditions. This research aims to use the results obtained from the two studies to analyze the indoor thermal comfort using the predicted mean vote (PMV). During the whole experimental tests the indoor humidity was kept at a level where the condensation risk was minimized and no condensation was detected on the chilled surface of the ceiling. Detailed experimental measurements on the air temperature distribution, surface temperature and globe temperature were realized for different cases where the cooling ceiling temperature varied from 16.9° to 18.9°C. The boundary conditions necessary for the CFD study were obtained from the experimental data measurements. The results of the simulations were first validated with the data from the experiments and then the air velocity fields were investigated. It was found that in the ankle/feet zone the air velocity could pass 0.2 m/s but for the rest of the zones it took values less than 0.1 m/s. The obtained experimental results for different chilled ceiling temperature showed that with a cooling ceiling the vertical temperature gradient is less than 1°C/m, which corresponds to the standards recommendations. A comparison between globe temperature and the indoor air temperature showed a maximum difference of 0.8°C being noticed. This paper also presents the radiosity method that it was used to calculate the mean radiant temperature for different positions along different axes. The method was based on the calculation of the view factors and on the surface temperatures obtained from the experiments. PMV plots showed that the thermal comfort is achieved and is uniformly distributed within the test room.