Gas phase folding of an (Ala)(4) neutral peptide chain: spectroscopic evidence for the formation of a beta-hairpin H-bonding pattern - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Physical Chemistry Chemical Physics Année : 2009

Gas phase folding of an (Ala)(4) neutral peptide chain: spectroscopic evidence for the formation of a beta-hairpin H-bonding pattern

Résumé

IR and UV laser spectroscopy of an Ala-based 4-residue model peptide recorded under gas phase isolated conditions provides evidence for the intrinsic stability of compact folded structures resembling the extremity of a beta-hairpin, with a C-14 H-bond bridging the two ends of the chain, and enables us to assess the capabilities of new quantum chemistry techniques to account for dispersive interactions in a medium-size molecule.

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hal-00450353 , version 1 (26-01-2010)

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Citer

Eric Gloaguen, R. Pollet, F. Piuzzi, B. Tardivel, M. Mons. Gas phase folding of an (Ala)(4) neutral peptide chain: spectroscopic evidence for the formation of a beta-hairpin H-bonding pattern. Physical Chemistry Chemical Physics, 2009, 11 (48), pp.11385-11388. ⟨10.1039/b918670k⟩. ⟨hal-00450353⟩
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