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Article Dans Une Revue European Polymer Journal Année : 2009

Shell-crosslinked nanoparticles through self-assembly of thermoresponsive block copolymers by RAFT polymerization

Résumé

A reversible addition-fragmentation chain transfer (RAFT) agent, the methyl-2-(n-butyltrithiocarbonyl)propanoate (MBTTCP) has shown to be efficient in controlling the polymerization of N,N-dimethylacrylamide (DMA), N-isopropylacrylamide (NIPAM) and N-acryloyloxysuccinimide (NAS). Two different strategies have been studied to synthesize block copolymers based on one PNIPAN block and the other a random copolymer of DMA and NAS. When a PNIPAM trithiocarbonate-terminated is used as macromolecular chain transfer agent for the polymerization of a mixture of NAS and DMA, well-defined P(NIPAM-b-(NAS-co-DMA)) block copolymers were obtained with a low polydispersity index. These thermoresponsive block copolymers dissolved in aqueous solution at 25 °C and self-assembled into micelles when the temperature was raised above the LCST of the PNIPAM block. The micelle shell containing NAS units was further crosslinked using a primary diamine in order to get shell-crosslinked nanoparticles. Upon cooling below the LCST of PNIPAM this structure may easily reorganize to form nanoparticles with a water filled hydrophilic core.

Dates et versions

hal-00441077 , version 1 (14-12-2009)

Identifiants

Citer

Sagrario Pascual, Michael J. Monteiro. Shell-crosslinked nanoparticles through self-assembly of thermoresponsive block copolymers by RAFT polymerization. European Polymer Journal, 2009, 45 (9), pp.2513-2519. ⟨10.1016/j.eurpolymj.2009.06.009⟩. ⟨hal-00441077⟩

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