Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Learning and Memory Année : 2009

Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors.

Résumé

Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of anandamide (a cannabinoid CB(1)-receptor ligand) and oleoylethanolamide and palmitoylethanolamide (OEA and PEA, ligands for alpha-type peroxisome proliferator-activated nuclear receptors, PPAR-alpha) when and where they are naturally released in the brain. Using a passive-avoidance task in rats, we found that memory acquisition was enhanced by the FAAH inhibitor URB597 or by the PPAR-alpha agonist WY14643, and these enhancements were blocked by the PPAR-alpha antagonist MK886. These findings demonstrate novel mechanisms for memory enhancement by activation of PPAR-alpha, either directly by administering a PPAR-alpha agonist or indirectly by administering a FAAH inhibitor.

Dates et versions

hal-00439503 , version 1 (07-12-2009)

Identifiants

Citer

Carmen Mazzola, Julie Medalie, Maria Scherma, Leigh V. Panlilio, Marcello Solinas, et al.. Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors.. Learning and Memory, 2009, 16 (5), pp.332-337. ⟨10.1101/lm.1145209⟩. ⟨hal-00439503⟩

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