Interaction forces of a supported DOPC bilayer in the presence of the general anaesthetic halothane - An atomic force microscopy study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Australian Journal of Chemistry Année : 2006

Interaction forces of a supported DOPC bilayer in the presence of the general anaesthetic halothane - An atomic force microscopy study

L. G. Shamrakov
  • Fonction : Auteur
Z. V. Leonenko
  • Fonction : Auteur
David T Cramb
  • Fonction : Auteur

Résumé

In this study atomic force microscopy (AFM) was used to study the effect of halothane on a supported dioleoylphosphatidylcholine ( DOPC) bilayer under conditions of high anaesthetic loading. In a previous study we demonstrated that bilayer restructuring occurs as a result of halothane incorporation. Force measurements using AFM indicate an initial decrease in adhesive forces and compressibility between the bilayer and AFM tip, followed by an increase in adhesion properties as a function of incubation time. This effect is attributed to the location and dynamic redistribution of halothane within the bilayer.
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Dates et versions

hal-00437306 , version 1 (30-11-2009)

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Citer

L. G. Shamrakov, Z. V. Leonenko, Eric Finot, David T Cramb. Interaction forces of a supported DOPC bilayer in the presence of the general anaesthetic halothane - An atomic force microscopy study. Australian Journal of Chemistry, 2006, 59 (6), pp.386-389. ⟨10.1071/CH06141⟩. ⟨hal-00437306⟩
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