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Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2009

Synthesis, reactivity and biological evaluation of novel halogenated tripentones.

Vittoria Perri
  • Fonction : Auteur
Christophe Rochais
Patrick Dallemagne
Sylvain Rault
  • Fonction : Auteur

Résumé

We describe herein the synthesis and the biological evaluation of a novel series of a potent anticancer agents: the tripentones. For the first time, a halogen atom was introduced in high yields on the pyrrole ring of the tricycle. This synthesis and the reactivity of the novel halogenated tripentones in metallo-catalysed cross-coupling reactions will be described in that article. Finally their influence on biological activity will be discussed.

Dates et versions

hal-00433244 , version 1 (18-11-2009)

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Citer

Vittoria Perri, Christophe Rochais, Thierry Cresteil, Patrick Dallemagne, Sylvain Rault. Synthesis, reactivity and biological evaluation of novel halogenated tripentones.. Bioorganic and Medicinal Chemistry, 2009, 17 (22), pp.7783-8. ⟨10.1016/j.bmc.2009.09.027⟩. ⟨hal-00433244⟩
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