Ototoxic and nephrotoxic drugs inhibit agonist-induced inositol phosphate formation in rat brain synaptoneurosomes. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Toxicology Letters Année : 1990

Ototoxic and nephrotoxic drugs inhibit agonist-induced inositol phosphate formation in rat brain synaptoneurosomes.

Résumé

Neomycin (an aminoglycoside antibiotic), ethacrynate (a loop diuretic), cisplatin (an anticancer drug) and mercuric chloride are chemically unrelated drugs which present similar ototoxic and nephrotoxic properties. We have found that all these molecules inhibit inositol phosphate turnover induced by carbachol or glutamate in rat brain synaptoneurosomes. Since this second messenger system appears to be a key mechanism for cell functioning and even survival, our observations raise the possibility that the expression of the specific toxicity of these compounds may result from excessive inhibition of the phosphoinositide cascade.

Dates et versions

hal-00422133 , version 1 (20-08-2019)

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Janique Guiramand, Marc Lenoir, Rémy Pujol, Max Récasens. Ototoxic and nephrotoxic drugs inhibit agonist-induced inositol phosphate formation in rat brain synaptoneurosomes.. Toxicology Letters, 1990, 51 (3), pp.331-8. ⟨10.1016/0378-4274(90)90076-X⟩. ⟨hal-00422133⟩
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