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Article Dans Une Revue Tetrahedron Letters Année : 2007

Synthesis of new tetrazole and triazole substituted pyroglutamic acid and proline derivatives

Résumé

Racemic 4-(substituted-1H-1,2,3-triazol-1-yl), 4-aryl and 4-(arylmethyl)tetrazolyl-pyroglutamic and proline derivatives were synthesized from dimethyl-2,4-dibromoglutaryle 1 in good yield using mild reaction conditions. The key step for the preparation of the triazole substituted molecule was the 1,3-dipolar cycloaddition of an acetylenic compound with an azido derivative. The tetrazole derivatives were prepared by the selective N2-alkylation of 5-substituted tetrazoles with 1. (c) 2006 Elsevier Ltd. All rights reserved.

Domaines

Chimie organique

Dates et versions

hal-00422059 , version 1 (05-10-2009)

Identifiants

Citer

F. Lenda, F. Guenoun, Jean Martinez, Frédéric Lamaty. Synthesis of new tetrazole and triazole substituted pyroglutamic acid and proline derivatives. Tetrahedron Letters, 2007, 48 (5), pp.805-808. ⟨10.1016/j.tetlet.2006.11.163⟩. ⟨hal-00422059⟩
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