Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: On the significance of the orientation and substitution at position 3 - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2008

Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: On the significance of the orientation and substitution at position 3

Résumé

The synthesis and structure-activity relationships concerning 3,4,5-trisubstituted 1,2,4-triazoles as ghrelin receptor ligands are described. The importance of the starting aminoacid material as well as its configuration was explored and the (D) Trp residue was found to lead to the best agonist or antagonist compounds. (C) 2007 Elsevier Ltd. All rights reserved.

Dates et versions

hal-00420056 , version 1 (28-09-2009)

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Aline Moulin, L. Demange, J. Ryan, Celine M'Kadmi, Jean-Claude Galleyrand, et al.. Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: On the significance of the orientation and substitution at position 3. Bioorganic and Medicinal Chemistry Letters, 2008, 18 (1), pp.164-168. ⟨10.1016/j.bmcl.2007.10.113⟩. ⟨hal-00420056⟩
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