A high-cycle fatigue life model for structures subjected to variable amplitude multiaxial loading is presented in this paper. It treats any kind of repeated blocks of variable amplitude multiaxial loading without using a cycle counting method. This model based on a mesoscopic approach is characterized by the following features: (i) the choice of a damage factor related to the accumulated mesoscopic plastic strain per stabilised cycle; (ii) the use of amesoscopicmechanical behaviour taking into account the fatigue mechanisms such as plasticity and void growth. This behaviour is a von Mises elastoplastic model with linear kinematic hardening and hydrostatic stress dependent yield stress. The fatigue life model has six parameters identified with one SN curve and two fatigue limits. In-phase and outof- phase experimental tests from the literature are simulated. The predicted fatigue lives are compared to experimental ones.