Bioresorbable and thermosensitive hydrogels prepared through stereocomplexation between poly(L-lactide) and poly(D-lactide) blocks attached to poly(ethylene glycol) - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Macromolecular Bioscience Année : 2003

Bioresorbable and thermosensitive hydrogels prepared through stereocomplexation between poly(L-lactide) and poly(D-lactide) blocks attached to poly(ethylene glycol)

Résumé

Block copolymers were synthesized by ring opening polymerization of L-lactide or D-lactide in the presence of mono- or dihydroxyl poly(ethylene glycol) (PEG), using zinc metal as catalyst. The composition of the copolymers was designed such that they were water soluble. Novel bioresorbable hydrogels were prepared from aqueous solutions containing both poly(L-lactide)/PEG and poly(D-lactide)/PEG block copolymers. In fact, stereocomplexation occurred between poly(L-lactide) and poly(D-lactide) blocks, leading to the formation of a hydrogel. A model protein drug, bovine serum albumin, was incorporated into the hydrogel for drug delivery studies. Data showed that the protein was released at a relatively constant rate over two weeks.

Domaines

Polymères

Dates et versions

hal-00418022 , version 1 (17-09-2009)

Identifiants

Citer

Suming Li. Bioresorbable and thermosensitive hydrogels prepared through stereocomplexation between poly(L-lactide) and poly(D-lactide) blocks attached to poly(ethylene glycol). Macromolecular Bioscience, 2003, 3, pp.657-661. ⟨10.1002/mabi.200350032⟩. ⟨hal-00418022⟩
57 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More