The hydrolytic degradation of various bioresorbable copolymers and blends derived from e-caprolatcone, DL-lactide and poly(ethylene glycol) (PEG) was investigated at 37°C in a pH 7.4 phosphate buffer. Poly(e-caprolatcone) (PCL) followed a slow degradation profile due to its hydrophobicity and crystallinity. The hydrophilicity and degradability of the materials can be improved by copolymerization with PEG and/or poly(DL-lactide) (PLA). Homogeneous degradation was shown in the cases of PCL, PCL/PEG copolymers and their blends, whereas PLA-containing copolymers followed a heterogeneous degradation due to internal autocatalysis. It is also shown that PCL-based materials gradually turned to PCL-enriched residues during degradation due to preferential hydrolysis of PLA segments and to diffusion of soluble species such as PLA oligomers and detached PEG blocks bearing short PLA segments. The results are discussed in comparison with literature data.