Fragmentation patterns of new esterified and unesterified aromatic 1-hydroxymethylene-1, 1-bisphosphonic acids by ESI-MSn - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Mass Spectrometry Année : 2008

Fragmentation patterns of new esterified and unesterified aromatic 1-hydroxymethylene-1, 1-bisphosphonic acids by ESI-MSn

Résumé

1-Hydroxymethylene-1,1-bisphosphonic acids (HMBPs) are compounds that have interesting pharmacological applications. Unfortunately few studies exist on their analyses by mass spectrometry (MS). In this work, we have analyzed new aromatic HMBPs and their prodrugs with electrospray tandem mass spectrometry (ESI-MSn). We describe, for the first time, a complete study of fragmentation patterns, in both positive and negative-ion modes. In positive mode, the cation dissociations are mainly elimination of water and phosphorus fragments. In negative mode, losses of ROH (R=H, C6H5, CH3OC6H5) and HPO2 were observed. The results have revealed specific structural fingerprints for the screening of these compounds in complex biological mixtures. Copyright (C) 2008 John Wiley & Sons, Ltd.

Dates et versions

hal-00416626 , version 1 (14-09-2009)

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Citer

J. Hardouin, E. Guenin, M. Monteil, M. Caron, M. Lecouvey. Fragmentation patterns of new esterified and unesterified aromatic 1-hydroxymethylene-1, 1-bisphosphonic acids by ESI-MSn. Journal of Mass Spectrometry, 2008, 43 (8), pp.1037-1044. ⟨10.1002/jms.1379⟩. ⟨hal-00416626⟩
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