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Article Dans Une Revue FEBS Letters Année : 2009

Fem1a is a mitochondrial protein up-regulated upon ischemia-reperfusion injury.

Résumé

Various expression studies have shown a preferential muscle expression of the mouse Fem1a gene, but no data is available on the subcellular localization of the corresponding protein. Here, using a specific antibody, we show that Fem1a is expressed preferentially in cardiac muscle, brain and liver. Moreover, using immunofluorescence and electron microscopy, as well as biochemical assays, we demonstrate that Fem1a is localized within mitochondria of C2C12 myoblasts and cardiac muscle cells. Finally, we show that the expression of Fem1a, which is a cellular partner of the EP4 receptor for prostaglandin E(2), is increased in mouse hearts after myocardial infarction.

Dates et versions

hal-00400156 , version 1 (30-06-2009)

Identifiants

Citer

Linda Cambier, Alain Lacampagne, Charles Auffray, Pascal Pomiès. Fem1a is a mitochondrial protein up-regulated upon ischemia-reperfusion injury.. FEBS Letters, 2009, 583 (10), pp.1625-30. ⟨10.1016/j.febslet.2009.04.035⟩. ⟨hal-00400156⟩
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