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Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 1998

Synthesis and biological activity of glutamic acid derivatives.

Résumé

In order to develop new specific glutamate analogues at metabotropic glutamate receptors, Diels-Alder, 1-4 ionic and radical reactions were performed starting from (2S)-4-methyleneglutamic acid. Preliminary pharmacological evaluation by measuring IP accumulation using rat forebrain synaptoneurosomes has shown that (2S)-4-(2-phthalimidoethyl)glutamic acid (3a), (2S)-4-(4-phthalimidobutyl)glutamic acid (3b) and 1-[(S)-2-amino-2-carboxyethyl]-3,4-dimethylcyclohex-3-ene-1-carbox ylic acid (8) presented moderate antagonist activities.

Dates et versions

hal-00397707 , version 1 (23-06-2009)

Identifiants

Citer

Jean-Marie Receveur, Janique Guiramand, Max Récasens, Marie-Louise Roumestant, P. Viallefont, et al.. Synthesis and biological activity of glutamic acid derivatives.. Bioorganic and Medicinal Chemistry Letters, 1998, 8 (2), pp.127-32. ⟨10.1016/S0960-894X(97)10208-6⟩. ⟨hal-00397707⟩
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