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Article Dans Une Revue European Journal of Organic Chemistry Année : 2009

Direct Access to L-Azetidine-2-carboxylic Acid

Résumé

A straightforward synthesis of L-azetidine-2-carboxylic acid is described, leading to both orthogonally protected versions or totally deprotected L-Aze. The starting material is a commercially available aspartic acid derivative, whose chirality is conserved. The (2-trimethylsilyl)ethaneslfonyl protecting group (SES) acts as a leaving group on the hydroxy function and serves as an activator for the amine function, which is the key-step of the reaction.
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Dates et versions

hal-00396956 , version 1 (19-06-2009)

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M\\\'Barek Bouazaoui, Jean Martinez, Florine Cavelier. Direct Access to L-Azetidine-2-carboxylic Acid. European Journal of Organic Chemistry, 2009, pp.2729-2732. ⟨10.1002/ejoc.200900233⟩. ⟨hal-00396956⟩
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