This study addressed the question of potential disorienting effects associated to head-mounted displays, by investigating the influence of a head-fixed visual frame on the perception of the vertical when the head is tilted in the frontal plane. Subject performance in indicating the vertical was contrasted with the effect of an earth-fixed visual frame as well as with the effect of tilting the head without a frame. With the tilted frames, subjects set the rod in an intermediate direction between the gravitational vertical and the orientation of the frame. Errors were strikingly larger with a head-fixed visual frame during head tilt than with a tilted earth-based frame. The increased effect cannot be attributed to the addition of a postural effect, due to the head being tilted. Moreover, continuous vision of the frame when its orientation changed improved performance only when the head and the frame were dissociated, i.e., with an earth-based frame. Those results suggest that integrating visual information in the head-centric reference frame is crucial for spatial orientation. This property of the perceptual system should be taken into account in the design of head-mounted displays for aeronautics.