To significantly increase the sampling rate of an ADC, timeinterleaved ADC (TIADC) is an efficient solution. Due to the manufacturing process, the main drawback of a TIADC system is that the M ADCs, which compose this end, are not exactly the same. This means that offset, gain and time mismatch errors are introduced. These errors cause distortions in the output sampled signal and introduce unwanted tones and noise, and hence, reduce the spurious free dynamic range (SFDR) as well as the signal to noise ratio (SNR). In this paper, we propose a new orthogonal digital calibration implementation, for timing skew, offset and gain mismatches, based on Code Division Multiple Access (CDMA) technique. Our calibration is online, this means that errors can be estimated while the ADC is running. Since most of the calibration processes are carried out on the digital outputs, very little change is needed on the analog part of the ADC. Simulation and implementation results show respectively the efficiency of our proposed calibration algorithm and our hardware implementation.