A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor. - Archive ouverte HAL
Article Dans Une Revue European Journal of Medicinal Chemistry Année : 2009

A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor.

Résumé

Rebeccamycin derivative 1 bearing a sugar moiety linked to both indole nitrogens and an amino substituent on the carbohydrate unit was synthesized in three steps from the bacterial metabolite. This compound was found to be a highly potent checkpoint kinase 1 inhibitor with an IC50 value of 2.8 nM.
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Dates et versions

hal-00371170 , version 1 (26-03-2009)

Identifiants

  • HAL Id : hal-00371170 , version 1

Citer

Fabrice Anizon, Roy Golsteyn, Stéphane Leonce, Bruno Pfeiffer, Michelle Prudhomme. A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor.. European Journal of Medicinal Chemistry, 2009, 44, pp.2234-2238. ⟨hal-00371170⟩
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