Electrophysiological studies of malaria parasite-infected erythrocytes: current status.
Henry M Staines
,
Abdulnaser Alkhalil
,
Richard J Allen
(1, 2)
,
Hugo R de Jonge
(3, 4)
,
Elvira Derbyshire
,
Stéphane Egée
(5)
,
Hagai Ginsburg
,
David R.C. Hill
(6, 7, 8, 9, 10)
,
Stephan M Huber
,
Kiaran Kirk
(11)
,
Florian Lang
(12, 13)
,
Godfrey Lisk
,
Eugene Oteng
,
Ajay D Pillai
,
Kempaiah Rayavara
,
Sherin Rouhani
,
Kevin J Saliba
,
Crystal Shen
(14, 15, 16)
,
Tsione Solomon
,
Serge L y Thomas
(5)
,
Patrick Verloo
,
Sanjay A Desai
1
School of Geographical Sciences [Bristol]
2 IMAG - Institut d'Informatique et de Mathématiques Appliquées de Grenoble
3 DB - Department of Biochemistry [Netherlands]
4 DCG - Department of Clinical Genetics
5 MS - Mer et santé
6 Development and Fetal Health
7 LIMOS - Laboratoire d'Informatique, de Modélisation et d'optimisation des Systèmes
8 Technische Hoschschule
9 CCSB - Center for Cancer Systems Biology
10 Department of Genetics [Boston]
11 School of Engineering and Science
12 VASY - System validation - Research and applications
13 Recherches en cancérologie
14 School of Science
15 NICTA - National ICT Australia [Sydney]
16 NIAID-NIH - National Institute of Allergy and Infectious Diseases [Bethesda]
2 IMAG - Institut d'Informatique et de Mathématiques Appliquées de Grenoble
3 DB - Department of Biochemistry [Netherlands]
4 DCG - Department of Clinical Genetics
5 MS - Mer et santé
6 Development and Fetal Health
7 LIMOS - Laboratoire d'Informatique, de Modélisation et d'optimisation des Systèmes
8 Technische Hoschschule
9 CCSB - Center for Cancer Systems Biology
10 Department of Genetics [Boston]
11 School of Engineering and Science
12 VASY - System validation - Research and applications
13 Recherches en cancérologie
14 School of Science
15 NICTA - National ICT Australia [Sydney]
16 NIAID-NIH - National Institute of Allergy and Infectious Diseases [Bethesda]
Henry M Staines
- Fonction : Auteur
Abdulnaser Alkhalil
- Fonction : Auteur
Elvira Derbyshire
- Fonction : Auteur
Hagai Ginsburg
- Fonction : Auteur
Stephan M Huber
- Fonction : Auteur
Godfrey Lisk
- Fonction : Auteur
Eugene Oteng
- Fonction : Auteur
Ajay D Pillai
- Fonction : Auteur
Kempaiah Rayavara
- Fonction : Auteur
Sherin Rouhani
- Fonction : Auteur
Kevin J Saliba
- Fonction : Auteur
Tsione Solomon
- Fonction : Auteur
Patrick Verloo
- Fonction : Auteur
Sanjay A Desai
- Fonction : Auteur
Résumé
The altered permeability characteristics of erythrocytes infected with malaria parasites have been a source of interest for over 30 years. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. However, conflicting results and differing interpretations of the data have led to confusion in this field. In an effort to unravel these issues, the groups involved recently came together for a week of discussion and experimentation. In this article, the various models for altered transport are reviewed, together with the areas of consensus in the field and those that require a better understanding.