IMGT(R), the international ImMunoGeneTics information system(R).
Résumé
IMGT, the international ImMunoGeneTics information system (http://www.imgt.org), was created
in 1989 by Marie-Paule Lefranc, Laboratoire
d’ImmunoGe´ ne´tique Mole´ culaire LIGM (Universite´
Montpellier 2 and CNRS) at Montpellier, France, in
order to standardize and manage the complexity of
immunogenetics data. The building of a unique
ontology, IMGT-ONTOLOGY, has made IMGT the
global reference in immunogenetics and immunoinformatics. IMGT is a high-quality integrated knowledge resource specialized in the immunoglobulins
or antibodies, T cell receptors, major histocompatibility complex, of human and other vertebrate
species, proteins of the IgSF and MhcSF, and
related proteins of the immune systems of any species. IMGT provides a common access to standardized data from genome, proteome, genetics and 3D
structures. IMGT consists of five databases (IMGT/
LIGM-DB, IMGT/GENE-DB, IMGT/3Dstructure-DB,
etc.), fifteen interactive online tools for sequence,
genome and 3D structure analysis, and more than
10 000 HTML pages of synthesis and knowledge.
IMGT is used in medical research (autoimmune
diseases, infectious diseases, AIDS, leukemias, lymphomas and myelomas), veterinary research, biotechnology related to antibody engineering (phage
displays, combinatorial libraries, chimeric, humanized and human antibodies), diagnostics (clonalities, detection and follow-up of residual diseases)
and therapeutical approaches (graft, immunotherapy, vaccinology).
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Licence : CC BY - Paternité
Licence : CC BY - Paternité