Carbonic anhydrase inhibitor coated gold nanoparticle selectively inhibit the tumor-associated isoform IX over the cytosolic ubiquitous isozymes I and II. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of the American Chemical Society Année : 2008

Carbonic anhydrase inhibitor coated gold nanoparticle selectively inhibit the tumor-associated isoform IX over the cytosolic ubiquitous isozymes I and II.

Résumé

An approach for the synthesis of carbonic anhydrase (CA, EC 4.2.1.1) inhibitor coated gold nanoparticles is reported. This nanomaterial selectively inhibited the tumor-associated isoform CA IX overexpressed in hypoxic cancers over the ubiquitous, cytosolic housekeeping isozymes CA I and II and was membrane impermeant. As CA IX has an extracellular active site, the new nanomaterial which is confined to the extracellular space may be useful for imaging and treatment of hypoxic tumors.

Dates et versions

hal-00356267 , version 1 (27-01-2009)

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Citer

Maamar Stiti, Alessandro Cecchi, Marouan Rami, Mohamed Abdaoui, Véronique Barragan-Montero, et al.. Carbonic anhydrase inhibitor coated gold nanoparticle selectively inhibit the tumor-associated isoform IX over the cytosolic ubiquitous isozymes I and II.. Journal of the American Chemical Society, 2008, 130, pp.16130-16131. ⟨10.1021/ja805558k⟩. ⟨hal-00356267⟩
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