Transient decrease in water diffusion observed in human occipital cortex during visual stimulation. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2001

Transient decrease in water diffusion observed in human occipital cortex during visual stimulation.

Résumé

Using MRI, we report the observation of a transient decrease of the apparent diffusion coefficient (ADC) of water in the human brain visual cortex during activation by a black and white 8-Hz-flickering checkerboard. The ADC decrease was small (<1%), but significant and reproducible, and closely followed the time course of the activation paradigm. Based on the known sensitivity of diffusion MRI to cell size in tissues and on optical imaging studies that have revealed changes in the shape of neurons and glial cells during activation, the observed ADC findings have been tentatively ascribed to a transient swelling of cortical cells. These preliminary results suggest a new approach to produce images of brain activation with MRI from signals directly associated with neuronal activation, and not through changes in local blood flow.

Domaines

Imagerie

Dates et versions

hal-00349815 , version 1 (04-01-2009)

Identifiants

Citer

A. Darquié, J. B. Poline, C. Poupon, Hervé Saint-Jalmes, D. Le Bihan. Transient decrease in water diffusion observed in human occipital cortex during visual stimulation.. Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 (16), pp.9391-5. ⟨10.1073/pnas.151125698⟩. ⟨hal-00349815⟩
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