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Article Dans Une Revue Journal of Magnetic Resonance Imaging Année : 2005

Optimization of a blood pool contrast agent injection protocol for MR angiography.

Résumé

PURPOSE: To design an ideal first-pass profile for MR angiography (MRA) by optimizing a multiphasic injection protocol based on two experimental animal models. MATERIALS AND METHODS: An equivalent contrast-enhanced (CE) MRA injection protocol was developed with controlled injection modalities (injection rate, volume, and dose) in rabbits and pigs. P792, a blood pool contrast agent, was injected in 17 male New Zealand rabbits and five farm pigs with variable injection schemes (mono- and multiphasic). From the gadolinium (Gd) blood concentration data, a simulation of an MR acquisition was performed to evaluate the impact of such an injection protocol on MR arterial signal and to select the best injection protocol. RESULTS: An empirical relationship between the arterial peak concentration and the injection parameters was found in the rabbits and pigs, allowing precise prediction of the first-pass profile. Of the four injection scheme strategies tested (standard bolus and bi-, tri-, and multiphasic injection protocols), the multiphasic "ramp" injection protocol provided the most optimal contrast agent pharmacokinetics with a durable plateau of concentration. CONCLUSION: Ramp injection protocol provides an optimized first-pass profile for CE-MRA.

Domaines

Imagerie

Dates et versions

hal-00349676 , version 1 (03-01-2009)

Identifiants

Citer

Philippe Robert, Xavier Violas, Robin Santus, Denis Le Bihan, Claire Corot. Optimization of a blood pool contrast agent injection protocol for MR angiography.. Journal of Magnetic Resonance Imaging, 2005, 21 (5), pp.611-9. ⟨10.1002/jmri.20324⟩. ⟨hal-00349676⟩
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