Direct and fast detection of neuronal activation in the human brain with diffusion MRI. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2006

Direct and fast detection of neuronal activation in the human brain with diffusion MRI.

Résumé

Using MRI, we found that a slowly diffusing water pool was expanding (1.7 +/- 0.3%) upon activation on the human visual cortex at the detriment of a faster diffusing pool. The time course of this water phase transition preceded the activation-triggered vascular response detected by usual functional MRI by several seconds. The observed changes in water diffusion likely reflect early biophysical events that take place in the activated cells, such as cell swelling and membrane expansion. Although the exact mechanisms remain to clarify, access to such an early and direct physiological marker of cortical activation with MRI will provide opportunities for functional neuroimaging of the human brain.

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Imagerie

Dates et versions

hal-00349661 , version 1 (03-01-2009)

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Citer

Denis Le Bihan, Shin-Ichi Urayama, Toshihiko Aso, Takashi Hanakawa, Hidenao Fukuyama. Direct and fast detection of neuronal activation in the human brain with diffusion MRI.. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (21), pp.8263-8. ⟨10.1073/pnas.0600644103⟩. ⟨hal-00349661⟩
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