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Article Dans Une Revue Magnetic Resonance in Medicine Année : 2008

In vivo single cell detection of tumor-infiltrating lymphocytes with a clinical 1.5T MRI system

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We demonstrate the feasibility of detecting individual tumor-infiltrating cells in vivo, by means of cellular magnetic labeling and a 1.5 Tesla clinical MRI device equipped with a high-resolution surface coil. Using a recently developed high-temperature superconducting (HTS) surface coil, single cells were detected in vitro in voxels of (60 μm)3 at magnetic loads as low as 0.2 pg of iron per cell. The same imaging protocol was used in vivo to monitor infiltration of ovalbumin-expressing tumors by transferred OVA antigen-specific cytotoxic lymphocytes with low iron load.

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hal-00348170 , version 1 (18-12-2008)

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Pierre Smirnov, Marie Poirier-Quinot, Claire Wilhelm, Elise Lavergne, Jean-Christophe Ginefri, et al.. In vivo single cell detection of tumor-infiltrating lymphocytes with a clinical 1.5T MRI system. Magnetic Resonance in Medicine, 2008, 60 (6), pp.1292-1297. ⟨10.1002/mrm.21812⟩. ⟨hal-00348170⟩
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