Interest of high shear wet granulation to produce drug loaded porous calcium phosphate pellets for bone filling - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2009

Interest of high shear wet granulation to produce drug loaded porous calcium phosphate pellets for bone filling

Résumé

Spherical porous calcium phosphate pellets were fabricated by high shear wet granulation using native starch as a binder. After a heat treatment to eliminate the organic template, pellets were loaded with ibuprofen by solvent evaporation method. In vitro drug release kinetics was determined using an USP II apparatus (Prolabo Dissolution Tester, France). Results showed the interest of the calcination and of the increase in the binder-porogen content, to improve the drug loading (higher drug content) and prolong the release of the drug substance.
Fichier non déposé

Dates et versions

hal-00345169 , version 1 (08-12-2008)

Identifiants

Citer

Marylène Viana, A. Desire, E. Chevalier, T.J. Champion, Roxana Chotard-Ghodsnia, et al.. Interest of high shear wet granulation to produce drug loaded porous calcium phosphate pellets for bone filling. 21st International Symposium on Ceramics in Medicine, The Annual Meeting of the International Society for Ceramics in Médicine (ISCM), Oct 2008, Buzios, Brazil. pp.535-538, ⟨10.4028/0-87849-353-0.535⟩. ⟨hal-00345169⟩
47 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More