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Article Dans Une Revue Comptes Rendus Biologies Année : 2006

The PAI-1 swing: Microenvironment and Cancer cell migration

Résumé

Cancer is a complex and dynamic process caused by a cellular dysfunction leading to a whole organ or even organism vital perturbation. To better understand this process we need to study each of the levels involved, what allows the scale change, and to integrate this knowledge. A matricellular protein, PAI-1, is able to induce in vitro cell behaviour modifications, morphological changes, and to promote cell migration. PAI-1 influences the mesenchymoamaeboid transition. This matricellular protein should be considered as a potential launcher of the metastatic process acting at the molecular, cellular, tissular levels and, as a consequence, at the organism's level.
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hal-00339600 , version 1 (23-05-2023)

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Michel Malo, Cécile Charrière-Bertrand, Chafika Chettaoui, Elisabeth Fabre-Guillevin, François Maquerlot, et al.. The PAI-1 swing: Microenvironment and Cancer cell migration. Comptes Rendus Biologies, 2006, 329 (12), pp.919--927. ⟨10.1016/j.crvi.2006.03.025⟩. ⟨hal-00339600⟩
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