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Article Dans Une Revue European Journal of Medicinal Chemistry Année : 2008

Synthesis and biological evaluation of diversely substituted indolin-2-ones

Résumé

The synthesis of indolin-2-one derivatives substituted in the 3-position by an aminomethylene group bearing either an ornithine or a lysine residue is described. The inhibitory activities of these compounds toward a panel of eight kinases were examined. Furthermore, the antibacterial activities of the prepared compounds were tested against two Gram-positive bacteria Bacillus cereus and Streptomyces chartreusis, a Gram-negative bacterium Escherichia coli and a yeast Candida albicans.
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Dates et versions

hal-00333575 , version 1 (23-10-2008)
hal-00333575 , version 2 (12-03-2009)

Identifiants

  • HAL Id : hal-00333575 , version 2

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Fadoua Bouchikhi, Emilie Rossignol, Martine Sancelme, Bettina Aboab, Fabrice Anizon, et al.. Synthesis and biological evaluation of diversely substituted indolin-2-ones. European Journal of Medicinal Chemistry, 2008, 43, pp.2316-2322. ⟨hal-00333575v2⟩
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