Molecular and Biochemical Characterization of SHV-56, a Novel Inhibitor-Resistant {beta}-Lactamase from Klebsiella pneumoniae.
Résumé
A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal blaSHV-56 gene, encoding a new inhibitor-resistant beta-lactamase of pI 7.6. SHV-56 derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.